Neuropathy stem cell treatment3/22/2023 ![]() The finding suggests that stem cell therapy could offer a practical option because stem cells from adipose tissue are relatively easy to obtain. Adipose-derived cells were found to be as efficacious as bone marrow-derived cells in reducing neuropathic pain in rats. One investigation compared the analgesic effects of MSC derived from bone marrow with MSC derived from adipose tissue. Cheng and his group has yielded new discoveries that bode well for MSC transplantation as a potential future treatment modality. Sources of neuropathic pain include alcoholism, amputation (which can result in phantom pain), some chemotherapy drugs (for example, Cisplatin®, Paclitaxel®, Vincristine®), radiation therapy, complex regional pain syndrome type II, trigeminal neuralgia, shingles, spinal stenosis, and central nervous system disorders, such as Parkinson disease and multiple sclerosis. However, hundreds of diseases are linked to neuropathic pain. Opioid analgesics can also lead to a variety of complications, ranging from itching and constipation to dependence, addiction, respiratory depression and death.Ībout 30 percent of neuropathy cases are caused by nerve damage associated with diabetes. Pain medicine researchers are searching for an alternative to opioid therapy because neuropathic pain often does not respond to morphine and other opioids. Cheng, Professor of Anesthesiology and Director of the Cleveland Clinic Multidisciplinary Pain Medicine Fellowship Program. These cells produced immune modulatory and anti-inflammatory effects, promoted sensory nerve repair, and showed strong analgesic properties that could provide a safer and more effective alternative to current treatment modalities, in the management of neuropathic pain, says Dr. MSC transplantation significantly reduced pain sensitivity evaluated by foot withdrawal thresholds in animals in response to thermal or mechanical stimulation. The group’s work has shown MSC transplantation’s effectiveness in reducing pain induced by sciatic nerve injury in rats and mice. ![]() ![]() Cheng and his colleagues have demonstrated the effectiveness of mesenchymal stem cell (MSC) transplantation in reducing hyperalgesia due to nerve injury. We do not endorse non-Cleveland Clinic products or services PolicyĪnimal studies by Dr. Advertising on our site helps support our mission. ![]() Cleveland Clinic is a non-profit academic medical center. ![]()
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